Monday, January 20, 2020

Personalized Nutrition -- Because Everything is Deeply Intertwingled!

Nutrition is hard to get right because everything is deeply intertwingled. Personalized Nutrition is changing that!

This new perspective on nutrition is gaining attention, as an aspect of personalized medicine, and is the subject of a new paper, Toward the Definition of Personalized Nutrition: A Proposal by The American Nutrition Association.  (I saw it as it was finalized, since my wife, Dana Reed, is a co-author, and a board member and part of the nutrition science team at ANA.)

The key idea is:
Personalized nutrition (PN) is rooted in the concept that one size does not fit all; differences in biochemistry, metabolism, genetics, and microbiota contribute to the dramatic inter-individual differences observed in response to nutrition, nutrient status, dietary patterns, timing of eating, and environmental exposures. PN has been described in a variety of ways, and other terms such as “precision nutrition,” “individualized nutrition,” and “nutritional genomics” have similar, sometimes overlapping, meanings in the literature.
I have always been something less than a poster child for following nutrition guidelines, for reasons that this report cites:  "...guidelines have only limited ability to address the myriad inputs that influence the unique manifestation of an individual’s health or disease status."

I frequently cite the conundrum from Woody Allen's Sleeper, when the 1970s protagonist had just been awakened by doctors after 200 years:
Dr. Melik: This morning for breakfast he requested something called "wheat germ, organic honey and tiger's milk."
Dr. Aragon: [chuckling] Oh, yes. Those are the charmed substances that some years ago were thought to contain life-preserving properties.
Dr. Melik: You mean there was no deep fat? No steak or cream pies or... hot fudge?
Dr. Aragon: Those were thought to be unhealthy... precisely the opposite of what we now know to be true.
Overstated to be sure, but the real issue is that "one man's meat is another man's poison." Determining which is which for a given person has been impractical, but now we are not only learning that this is far more intertwingled than was thought, but we are gaining the ability to tease out what applies to a given person.

I come from this not from biology, but from machine learning and predictive analytics. My focus is on getting smarter about how everything is intertwingled.

One of the most intriguing companies I have run across is Nutrino, a startup acquired by Medtronic, that analyzes data from continuous glucose monitors used by diabetics to understand the factors that affect their glucose response over time. They correlate to specific food intakes, activity, sleep, mood, blood tests, genomics, biomics, and more. They call it a FoodPrint, "a digital signature of how our body reacts to different foods. It is contextually driven and provides correlations, insights and predictions that become the underpinning for personal and continually improving nutrition recommendations." This is one of the first successful efforts to tease out how what I eat (and what else I do) really affects me as an individual, in all of its real-world intertwingularity.

It is time to move beyond the current so-called "gold standard" of intervention-based studies, the randomized double blind placebo controlled (RDBPC) clinical tests. Reality is far too intertwingled for that to be more than narrowly useful. It is time to embrace big data, correlation, and predictive analytics. Some early recognition of this is that drugmakers are getting the FDA to accept mining of patient data as a way to avoid need for clinical trials.

We have a long way to go, but I want to know how likely it is that a given amount of deep fat or hot fudge, or wheat germ or kale (in combination with the rest of my diet, behavior and risk factors), will have a significant effect, over a time frame that can motivate whether or not I indulge in my chocolate or eat my spinach.

It is not enough to know that the dose makes the poison -- I want to know if the average man's poison is really just my meat.

Before very long we will know.

23 comments:

  1. We are offering Best Digital marketing course in Bangalore with Live Projects. 100% placement, 20+ modules, 10+ certifications, Great discounts on course fees. Please visit our website to know more information.
    https://onlineidealab.com/digital-marketing-courses-in-bangalore/

    ReplyDelete
  2. I was very happy to find this site. I really enjoyed reading this article today and think it might be one of the best articles I have read so far. I wanted to thank you for this excellent reading !! I really enjoy every part and have bookmarked you to see the new things you post. Well done for this excellent article. Please keep this work of the same quality.
    Data Science Course in Bangalore

    ReplyDelete
  3. i am glad to discover this page : i have to thank you for the time i spent on this especially great reading !! i really liked each part and also bookmarked you for new information on your site.
    data science courses in hyderabad

    ReplyDelete
  4. Excellent Blog! I would like to thank for the efforts you have made in writing this post. I am hoping the same best work from you in the future as well. I wanted to thank you for this websites! Thanks for sharing. Great websites!
    Data Science Training in Bangalore

    ReplyDelete
  5. I Want to leave a little comment to support and wish you the best of luck.we wish you the best of luck in all your blogging endeavors.
    data science course in bangalore with placement

    ReplyDelete
  6. I am a new user of this site, so here I saw several articles and posts published on this site, I am more interested in some of them, hope you will provide more information on these topics in your next articles.
    data analytics training in bangalore

    ReplyDelete
  7. I just got to this amazing site not long ago. I was actually captured with the piece of resources you have got here. Big thumbs up for making such wonderful blog page!
    data analytics course in bangalore

    ReplyDelete
  8. I want to leave a little comment to support and wish you the best of luck.we wish you the best of luck in all your blogging endeavours.
    data science certification in bangalore

    ReplyDelete
  9. Great post i must say and thanks for the information. Education is definitely a sticky subject. However, is still among the leading topics of our time. I appreciate your post and look forward to more.
    Data Science Course in Bangalore

    ReplyDelete
  10. Great post i must say and thanks for the information. Education is definitely a sticky subject. However, is still among the leading topics of our time. I appreciate your post and look forward to more.
    Data Science Course in Bangalore

    ReplyDelete
  11. Thanks for posting the best information and the blog is very helpful.data science institutes in hyderabad

    ReplyDelete
  12. i am glad to discover this page : i have to thank you for the time i spent on this especially great reading !! i really liked each part and also bookmarked you for new information on your site.
    data scientist course in bangalore

    ReplyDelete
  13. i am glad to discover this page : i have to thank you for the time i spent on this especially great reading !! i really liked each part and also bookmarked you for new information on your site.
    best data science courses in bangalore

    ReplyDelete
  14. I just got to this amazing site not long ago. I was actually captured with the piece of resources you have got here. Big thumbs up for making such wonderful blog page!
    data analytics course in bangalore

    ReplyDelete
  15. I want to leave a little comment to support and wish you the best of luck.we wish you the best of luck in all your blogging enedevors.
    data analytics courses in bangalore

    ReplyDelete
  16. i am glad to discover this page : i have to thank you for the time i spent on this especially great reading !! i really liked each part and also bookmarked you for new information on your site.
    data science course

    ReplyDelete
  17. I want to leave a little comment to support and wish you the best of luck.we wish you the best of luck in all your blogging enedevors.
    data science course in chennai

    ReplyDelete
  18. Thanks for posting the best information and the blog is very important.artificial intelligence course in hyderabad

    ReplyDelete
  19. I am glad to discover this page. I have to thank you for the time I spent on this especially great reading !! I really liked each part and also bookmarked you for new information on your site.
    Data Science Training in Chennai

    ReplyDelete
  20. I am a new user of this site, so here I saw several articles and posts published on this site, I am more interested in some of them, hope you will provide more information on these topics in your next articles.
    data analytics training in bangalore

    ReplyDelete
  21. Excellent effort to make this blog more wonderful and attractive.
    business analytics course

    ReplyDelete